Here is a list of significant Karakatwas (significations) related to the 12th house:

1. Moksha (Liberation) – Spiritual liberation and freedom from the cycle of birth and death.
2. Isolation – Solitude, seclusion, and time spent in isolation.
3. Foreign Lands – Travel to or residence in foreign countries.
4. Expenses – Expenditures, financial losses, and spending.
5. Losses – Material and emotional losses.
6. Endings – The conclusion of cycles, endings, and closures.
7. Spirituality – Deep spiritual practices and connection to the divine.
8. Meditation – Practices related to meditation, contemplation, and inner reflection.
9. Subconscious Mind – The realm of the subconscious, dreams, and the hidden mind.
10. Secrets – Hidden matters, secrets, and things kept away from public view.
11. Sleep – Sleep patterns, rest, and the state of dreaming.
12. Imprisonment – Confinement, imprisonment, and situations of restriction.
13. Hospitals – Hospitals, asylums, and places of healing or confinement.
14. Monasteries – Monasteries, hermitages, and places of spiritual retreat.
15. Charity – Acts of charity, donation, and selfless service.
16. Isolation from Society – Separation from societal norms and expectations.
17. Introspection – Self-reflection, introspection, and looking within.
18. Dreams – The content and significance of dreams.
19. Hidden Enemies – Enemies that work in secrecy or behind the scenes.
20. Karma from Past Lives – The results of past life actions (Karmic debts).
21. Exile – Being in exile, either physically or metaphorically.
22. Secret Affairs – Involvement in secret relationships or activities.
23. Emotional Release – Letting go of emotional baggage and healing from past traumas.
24. Philanthropy – Philanthropic efforts and supporting others without seeking returns.
25. Research – Deep research, investigation, and exploration of hidden matters.
26. Mysticism – Involvement in mystical or esoteric practices.
27. Sacrifice – Acts of self-sacrifice for the benefit of others.
28. Detachment – Detachment from material possessions and worldly concerns.
29. Healing – Healing from physical, emotional, or spiritual wounds.
30. Retreats – Going on retreats, whether spiritual or for mental rejuvenation.
31. Solitude – Embracing solitude as a means of self-discovery and growth.
32. Foreign Travel – Long-distance travel, especially to remote or foreign places.
33. Asceticism – Practices related to ascetic living and renunciation.
34. Prison – Physical or metaphorical imprisonment, or being confined in some way.
35. Hospice – Involvement with hospice care or end-of-life services.
36. Occult Knowledge – Knowledge of the occult, hidden sciences, or esoteric teachings.
37. Secrets Revealed – The uncovering of hidden truths or secrets.
38. Escapism – The tendency to escape from reality, either through fantasy or substances.
39. Artistic Inspiration – Inspiration for art, especially from dreams or the subconscious.
40. Withdrawal – Withdrawal from society or social engagements.
41. Psychic Abilities – The development or use of psychic abilities.
42. Isolation for Growth – Using isolation as a tool for personal or spiritual growth.
43. Loss of Ego – Letting go of the ego, pride, or self-importance.
44. Compassion – Deep compassion for others, often leading to acts of kindness.
45. Long-Term Illness – Chronic health issues that may require extended care.
46. Final Liberation – Attaining Moksha, or liberation from the cycle of rebirth.
47. Non-Attachment – Practicing non-attachment to material possessions or relationships.
48. Hidden Talents – Discovering or using talents that are not immediately obvious.
49. Reclusive Life – Choosing a reclusive or solitary lifestyle.
50. Self-Sacrifice – Sacrificing personal desires for the greater good.
51. Astral Travel – Experiences related to astral projection or out-of-body experiences.
52. Immigration – Moving to a foreign country or dealing with issues related to immigration.
53. Loss of Relationships – The end of relationships or partnerships.
54. Charitable Institutions – Involvement with or support for charitable organizations.
55. Mental Health – Issues related to mental health, anxiety, or depression.
56. Unconscious Mind – Exploring the depths of the unconscious mind.
57. End-of-Life Matters – Concerns related to death, dying, and what lies beyond.
58. Addictions – Struggles with addictions or compulsive behaviors.
59. Hidden Wealth – Wealth that is not immediately visible, such as secret savings or inheritance.
60. Hidden Sorrow – Suffering or sadness that is kept private.
61. Forgiveness – The process of forgiving others and oneself.
62. Escapes – Desire to escape from reality, whether through travel, fantasy, or substance use.
63. Mystical Experiences – Encounters with the mystical or supernatural.
64. Karmic Debt – Paying off debts from past lives or previous actions.
65. Dissolution – The dissolution of structures, whether personal, social, or material.
66. Letting Go – Learning to let go of attachments and expectations.
67. Secret Knowledge – Gaining access to secret or forbidden knowledge.
68. Foreign Cultures – Interest in or interaction with foreign cultures and traditions.
69. Hidden Suffering – Suffering that is not visible to others, often related to emotional or spiritual pain.
70. Hidden Enemies Revealed – The eventual uncovering of hidden enemies or adversaries.
71. Foreign Affairs – Involvement in international relations or foreign affairs.
72. Spiritual Retreats – Going on spiritual retreats for self-discovery and growth.
73. Voluntary Isolation – Choosing to isolate oneself for personal reasons.
74. Self-Undoing – Actions that lead to one’s downfall or self-sabotage.
75. Spiritual Sacrifice – Sacrificing material comforts for spiritual growth.
76. Dream Interpretation – The practice of interpreting dreams for guidance or insight.
77. Liberation from Materialism – Moving beyond material concerns to focus on spiritual goals.
78. Death and Rebirth – Symbolic or literal experiences of death and rebirth.
79. Withdrawal from the World – A deliberate withdrawal from worldly concerns.
80. Spiritual Healing – Healing that takes place on a spiritual or energetic level.
81. Charitable Giving – Donating time, money, or resources to those in need.
82. Loss of Identity – Letting go of personal identity or ego.
83. End-of-Life Care – Providing care for those nearing the end of their life.
84. Healing through Solitude – Finding healing and peace through time spent alone.
85. Subconscious Influences – How the subconscious mind affects conscious behavior.
86. Invisible Help – Receiving help or guidance from unseen sources.
87. Surrender – Surrendering to a higher power or to the flow of life.
88. Hidden Relationships – Involvement in relationships that are kept secret.
89. Karmic Resolution – Resolving karmic issues from past lives.
90. Clairvoyance – Developing or using the ability to see beyond the physical realm.
91. Secret Fears – Fears or anxieties that are kept hidden from others.
92. Crossing Over – The process of transitioning from life to death.
93. Hidden Strengths – Strengths or abilities that are not immediately apparent.
94. Service to Others – Engaging in service-oriented work without seeking recognition.
95. Withdrawal from Attachments – Detaching from emotional or material attachments.
96. End of a Cycle – The completion of a major life cycle or phase.
97. Immigration Matters – Issues related to immigration, visas, or foreign residency.
98. Divine Inspiration – Receiving inspiration from a higher or spiritual source.
99. Altruism – Acting out of concern for the well-being of others, often anonymously.
100. Ultimate Liberation – Attaining freedom from all earthly attachments and the cycle of rebirth.

These Karakatwas of the 12th house emphasize its role in representing the hidden, the spiritual, and the transcendent aspects of life. The 12th house is a complex and deeply spiritual part of the birth chart, focusing on matters beyond the material world, including liberation, inner peace, and the mysteries of existence.